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Chemotherapy Reaction in Oncology - Printable Version

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Chemotherapy Reaction in Oncology - JackieDemmy - 07-07-2021

Chemotherapy Reaction in Oncology
Created Feb 2021

Contact Information

     Developed by: Demmy, Jackie
     Developed for: BC Cancer Agency/Fraser Health Authority
     Submitted by: JackieDemmy
     Contact Email: simulation@fraserhealth.ca
     Peer Reviewed: <strong>Yes</strong> (The information is provided below)

Scenario Information

     Case Summary:

     ­A 58-year-old patient with ovarian cancer is receiving a new infusion of GOOVCATM  (paclitaxel and carboplatin). She develops back pain, weakness and hypotension. The team must recognize a moderate (Grade II) reaction, escalate to MRP, and manage the symptoms via medications, halt infusion, and plan restarting.

     Target Learning Groups:

      Physicians, Nursing, Specialist, Interprofessional Team

     Additional Target Learning Groups:


     Proposed Setting:

     Fraser Health In-patient Oncology, BC Cancer Agency Chemotherapy

     Educational Goals:

     ­1. Recognizes moderate reaction to paclitaxel infusion and defines per grading scale (Grade II)
2. Differentiates between non-antibody mediated reaction (cytokine storm versus and anaphylaxis)
3. Utilizes available resources  to manage infusion and treat reaction (supplied: BC Cancer Agency
        Protocol for Management of Infusion-Related Reactions to Systemic Therapy Agents (2021))
4. Utilizes SBAR to report reaction to MRP

Peer Review Information

Clinical Content Peer Review

      Clinical Content Reviewer: C Heywood Reviewed on: 02/21/2021

      Notes on Clinical Content Peer Review:


Simulation/Educational Review

     Simulation/Educational Reviewer: Jackie Demmy Reviewed on: 07/06/2021

     Notes on Simulation/Educational Peer Review:


Simulation/Educational Real Time Review

     Simulation/Educational Real Time Reviewer: Jackie Demmy Reviewed on: 02/22/2021

     Notes on Simulation/Educational Real Time Peer Review:


Extra Information

     Additional Details:



   See scenario for references

     Scenario Links:

     ­­BC Cancer Protocol Summary for Primary Treatment of No Visible Residual (Moderate-High Risk) Invasive Epithelial Ovarian, Fallopian Tube and Primary Peritoneal Cancer Using CARBOplatin and PACLitaxel

PROTOCOL CODE: SCDRUGRX Preprinted Order A: Immediate management of infusion-related reaction and resumption of infusion

BC Cancer Protocol Summary for Management of Infusion-Related Reactions to Systemic Therapy Agents

     Additional Tags: Chemotherapy, reaction, cancer,  cytokine storm

If you would like further information about this scenario please contact simulation@fraserhealth.ca or leave a comment below.